{"id":185,"date":"2025-03-04T14:55:29","date_gmt":"2025-03-04T14:55:29","guid":{"rendered":"https:\/\/euthanasiasleep.com\/?post_type=product&p=185"},"modified":"2026-03-29T01:00:44","modified_gmt":"2026-03-29T01:00:44","slug":"nembutal-powder","status":"publish","type":"product","link":"https:\/\/euthanasiasleep.com\/it\/prodotto\/nembutal-powder\/","title":{"rendered":"Nembutal in polvere per l'eutanasia"},"content":{"rendered":"

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Not to be confused with\u00a0phenobarbital<\/a>\u00a0or\u00a0sodium pentothal<\/a>.<\/div>\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n
Pentobarbital<\/span><\/caption>\n
<\/a><\/span><\/td>\n<\/tr>\n
<\/a><\/span><\/td>\n<\/tr>\n
Clinical data<\/th>\n<\/tr>\n
Trade names<\/a><\/th>\nNembutal<\/td>\n<\/tr>\n
AHFS<\/a>\/Drugs.com<\/a><\/th>\nMonograph<\/a><\/span><\/td>\n<\/tr>\n
MedlinePlus<\/a><\/th>\na682416<\/a><\/span><\/td>\n<\/tr>\n
License data<\/a><\/th>\n\n
\n
Pregnancy
\ncategory<\/a><\/th>\n		\n
\n
    \n
  • AU<\/abbr>:<\/small>\u00a0C<\/li>\n<\/ul>\n<\/div>\n<\/td>\n<\/tr>\n
Routes of
\nadministration<\/a><\/th>\n		By mouth<\/a>,\u00a0intravenous<\/a>,\u00a0intramuscular<\/a>,\u00a0rectal<\/a><\/td>\n<\/tr>\n
Drug class<\/a><\/th>\nBarbiturate<\/a><\/td>\n<\/tr>\n
ATC code<\/a><\/th>\n\n
\n
Legal status<\/th>\n<\/tr>\n
Legal status<\/a><\/th>\n\n
\n
Pharmacokinetic<\/a>\u00a0data<\/th>\n<\/tr>\n
Bioavailability<\/a><\/th>\n70\u201390% (oral); 90% (rectal)<\/td>\n<\/tr>\n
Protein binding<\/a><\/th>\n20\u201345%<\/td>\n<\/tr>\n
Metabolism<\/a><\/th>\nLiver<\/a><\/td>\n<\/tr>\n
Elimination\u00a0half-life<\/span><\/a><\/th>\n15\u201348 hours<\/td>\n<\/tr>\n
Excretion<\/a><\/th>\nKidney<\/a><\/td>\n<\/tr>\n
Identifiers<\/th>\n<\/tr>\n
\n
\n

CAS Number<\/a><\/th>\n\n
\n
PubChem<\/a>\u00a0CID<\/abbr><\/th>\n\n
\n
IUPHAR\/BPS<\/a><\/th>\n\n
\n
DrugBank<\/a><\/th>\n\n
\n
ChemSpider<\/a><\/th>\n\n
\n
UNII<\/a><\/th>\n\n
\n
KEGG<\/a><\/th>\n\n
\n
ChEBI<\/a><\/th>\n\n
\n
ChEMBL<\/a><\/th>\n\n
\n
CompTox Dashboard<\/a>\u00a0(EPA<\/abbr>)<\/th>\n\n
\n
ECHA InfoCard<\/span><\/a><\/th>\n100.000.895<\/a>\u00a0\"Edit<\/a><\/span><\/td>\n<\/tr>\n
Chemical and physical data<\/th>\n<\/tr>\n
Formula<\/a><\/th>\nC<\/span>11<\/sub>H<\/span>18<\/sub>N<\/span>2<\/sub>O<\/span>3<\/sub><\/td>\n<\/tr>\n
Molar mass<\/a><\/th>\n226.276<\/span>\u00a0g\u00b7mol\u22121<\/sup><\/td>\n<\/tr>\n
3D model (JSmol<\/a>)<\/th>\n\n
\n
\n
\n

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\u00a0\u00a0(verify)<\/a><\/span><\/span><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

Pentobarbital<\/b>\u00a0(US) or\u00a0pentobarbitone<\/b>\u00a0(British and Australian) is a short-acting\u00a0barbiturate<\/a>\u00a0typically used as a\u00a0sedative<\/a>, a\u00a0preanesthetic<\/a>, and to control\u00a0convulsions<\/a>\u00a0in emergencies.[<\/span>3]<\/span><\/a><\/sup>\u00a0It can also be used for short-term treatment of\u00a0insomnia<\/a>\u00a0but has been largely replaced by the\u00a0benzodiazepine<\/a>\u00a0family of drugs.<\/p>\n

In high doses, pentobarbital causes death by\u00a0respiratory arrest<\/a>. It is used for\u00a0veterinary euthanasia<\/a>\u00a0and is used by some US states and the\u00a0United States federal government<\/a>\u00a0for\u00a0executions<\/a>\u00a0of convicted criminals by\u00a0lethal injection<\/a>.[<\/span>4]<\/span><\/a><\/sup>\u00a0In some countries and states, it is also used for\u00a0physician-assisted suicide<\/a>.[<\/span>5]<\/span><\/a><\/sup>[<\/span>6]<\/span><\/a><\/sup><\/p>\n

Pentobarbital was widely\u00a0abused<\/a>\u00a0beginning in the late 1930s and sometimes known as “yellow jackets” due to the yellow color of Nembutal-branded capsules.[<\/span>7]<\/span><\/a><\/sup><\/p>\n

Pentobarbital was developed by\u00a0Ernest H. Volwiler<\/a>\u00a0and\u00a0Donalee L. Tabern<\/a>\u00a0[de<\/a>]<\/span>\u00a0at\u00a0Abbott Laboratories<\/a>\u00a0in 1930.<\/p>\n

\n

Uses<\/h2>\n

[<\/span>edit<\/a>]<\/span><\/span><\/p>\n<\/div>\n

\n

Medical<\/h3>\n

[<\/span>edit<\/a>]<\/span><\/span><\/p>\n<\/div>\n

Typical applications for pentobarbital are\u00a0sedative<\/a>, short term\u00a0hypnotic<\/a>,\u00a0preanesthetic<\/a>,\u00a0insomnia<\/a>\u00a0treatment, and control of\u00a0convulsions<\/a>\u00a0in emergencies.[<\/span>3]<\/span><\/a><\/sup>\u00a0Abbott Pharmaceutical discontinued manufacture of their Nembutal brand of Pentobarbital capsules in 1999, largely replaced by the benzodiazepine family of drugs.<\/p>\n

Pentobarbital can reduce intracranial pressure in\u00a0Reye’s syndrome<\/a>, treat traumatic brain injury and induce coma in\u00a0cerebral ischemia<\/a>\u00a0patients.[<\/span>8]<\/span><\/a><\/sup>\u00a0Pentobarbital-induced coma has been advocated in patients with\u00a0acute liver failure<\/a>\u00a0refractory<\/a>\u00a0to\u00a0mannitol<\/a>.[<\/span>9]<\/span><\/a><\/sup><\/p>\n

Pentobarbital is also used as a veterinary anesthetic agent.[<\/span>10]<\/span><\/a><\/sup><\/p>\n

\n

Euthanasia and assisted suicide<\/h3>\n

[<\/span>edit<\/a>]<\/span><\/span><\/p>\n<\/div>\n

Pentobarbital can cause death when used in high doses<\/a>. It is used for\u00a0euthanasia<\/a>\u00a0for humans as well as animals. It is taken alone, or in combination with complementary agents such as\u00a0phenytoin<\/a>, in commercial\u00a0animal euthanasia<\/a>\u00a0injectable solutions.[<\/span>5]<\/span><\/a><\/sup>[<\/span>6]<\/span><\/a><\/sup><\/p>\n

<\/a>
Pentobarbital sodium (CAS No. 57-33-0)<\/figcaption><\/figure>\n

In the\u00a0Netherlands<\/a>, pentobarbital is part of the standard protocol for\u00a0physician-assisted suicide<\/a>\u00a0for self-administration by the patient.[<\/span>11]<\/span><\/a><\/sup>\u00a0It is given in liquid form, in a solution of sugar syrup and\u00a0alcohol<\/a>, containing 9 grams of pentobarbital. This is preceded by an\u00a0antiemetic<\/a>\u00a0to prevent vomiting.[<\/span>11]<\/span><\/a><\/sup><\/p>\n

It is taken by mouth for physician-assisted death in the United States states of Oregon, Washington, Vermont, and California (as of January 2016).[<\/span>12]<\/span><\/a><\/sup>[<\/span>13]<\/span><\/a><\/sup>\u00a0The oral dosage of pentobarbital indicated for physician-assisted suicide in Oregon is typically 10 g of liquid.[<\/span>12]<\/span><\/a><\/sup>[<\/span>13]<\/span><\/a><\/sup><\/p>\n

In\u00a0Switzerland<\/a>, sodium pentobarbital is administered to the patient\u00a0intravenously<\/a>. Once administered, sleep is induced within 30 seconds, and the heart stops beating within 3 minutes.[<\/span>14]<\/span><\/a><\/sup>\u00a0Oral administration is also used. A Swiss pharmacist reported in 2022 that the dose for assisted suicide had been raised to 15 grams because with lower doses death was preceded by a coma of up to 10 hours in some cases.[<\/span>15]<\/span><\/a><\/sup><\/p>\n

\n

Execution<\/h3>\n

[<\/span>edit<\/a>]<\/span><\/span><\/p>\n<\/div>\n

Pentobarbital has been used or considered as a substitute for the barbiturate\u00a0sodium thiopental<\/a>\u00a0used for\u00a0capital punishment<\/a>\u00a0by\u00a0lethal injection<\/a>\u00a0in the United States when that drug became unavailable.[<\/span>16]<\/span><\/a><\/sup>\u00a0In 2011 the U.S. manufacturer of sodium thiopental stopped production, and importation of the drug proved impossible. Pentobarbital was used in a U.S. execution for the first time in December 2010 in Oklahoma, as part of a three-drug protocol.[<\/span>16]<\/span><\/a><\/sup>\u00a0In March 2011 pentobarbital was used for the first time as the sole drug in a U.S. execution, in Ohio. Since then several states as well as the federal government have used pentobarbital for lethal injections; some use three-drug protocols and others use pentobarbital alone.<\/p>\n

Pentobarbital is produced by the Danish company\u00a0Lundbeck<\/a>. Use of the drug for executions is illegal under Danish law, and when this was discovered, after public outcry in Danish media, Lundbeck stopped selling it to US states that impose the\u00a0death penalty<\/a>\u00a0and prohibited US distributors from selling it to any customers, such as state authorities, that practice or participate in executions of humans.[<\/span>17]<\/span><\/a><\/sup><\/p>\n

Texas began using the single-drug pentobarbital protocol for executing death-row inmates on 18 July 2012,[<\/span>18]<\/span><\/a><\/sup>\u00a0because of a shortage of\u00a0pancuronium bromide<\/a>, a muscle paralytic previously used as one component of a three-drug cocktail.[<\/span>18]<\/span><\/a><\/sup>\u00a0In October 2013,\u00a0Missouri<\/a>\u00a0changed its protocol to allow for pentobarbital from a\u00a0compounding pharmacy<\/a>\u00a0to be used in a lethal dose for executions.[<\/span>19]<\/span><\/a><\/sup>\u00a0It was first used in November 2013.[<\/span>20]<\/span><\/a><\/sup>[<\/span>21]<\/span><\/a><\/sup><\/p>\n

According to a December 2020\u00a0ProPublica<\/a>\u00a0article, by 2017 the federal\u00a0Bureau of Prisons<\/a>\u00a0(BOP), in discussion with then Attorney General\u00a0Jeff Sessions<\/a>, had begun to search for suppliers of pentobarbital to be used in lethal injections. The BOP was aware that the use of pentobarbital as their “new drug choice” would be challenged in the courts because some lawyers had said that “pentobarbital would flood prisoners’ lungs with froth and foam, inflicting pain and terror akin to a death by drowning.” BOP claimed that these concerns were unjustified and that their two expert witnesses asserted that the use of pentobarbital was “humane”.[<\/span>22]<\/span><\/a><\/sup>\u00a0On 25 July 2019,\u00a0US Attorney General<\/a>\u00a0William Barr<\/a>\u00a0directed the federal government to resume capital punishment after 16 years.[<\/span>23]<\/span><\/a><\/sup>\u00a0The federal protocol provides for intravenous administration of two syringes each containing 2.5 grams of pentobarbital sodium followed by a saline flush.[<\/span>24]<\/span><\/a><\/sup><\/p>\n

\n

Pharmacology<\/h2>\n

[<\/span>edit<\/a>]<\/span><\/span><\/p>\n<\/div>\n

\n

Pharmacodynamics<\/h3>\n

[<\/span>edit<\/a>]<\/span><\/span><\/p>\n<\/div>\n

Like other barbiturates, pentobarbital binds to the barbiturate-binding site on the\u00a0GABA-A receptor<\/a>. This action increases the duration of ion-channel opening. At high doses, pentobarbital is capable of opening the ion channel in the absence of\u00a0GABA<\/a>.[<\/span>25]<\/span><\/a><\/sup><\/p>\n

\n

Pharmacokinetics<\/h3>\n

[<\/span>edit<\/a>]<\/span><\/span><\/p>\n<\/div>\n

Pentobarbital undergoes\u00a0first-pass metabolism<\/a>\u00a0in the liver and possibly the intestines.[<\/span>26]<\/span><\/a><\/sup><\/p>\n

\n

Drug interactions<\/h2>\n

[<\/span>edit<\/a>]<\/span><\/span><\/p>\n<\/div>\n

The administration of ethanol<\/a>,\u00a0benzodiazepines<\/a>,\u00a0opioids<\/a>,\u00a0antihistamines<\/a>, other\u00a0sedative-hypnotics<\/a>, and other\u00a0central nervous system depressants<\/a>\u00a0will cause possible additive effects.[<\/span>8]<\/span><\/a><\/sup><\/p>\n

\n

Chemistry<\/h2>\n

[<\/span>edit<\/a>]<\/span><\/span><\/p>\n<\/div>\n

Pentobarbital is synthesized by methods analogous to that of\u00a0amobarbital<\/a>, the only difference being that the alkylation of \u03b1-ethylmalonic ester is carried out with 2-bromopentane in place of 1-bromo-3-methylbutane to give pentobarbital.[<\/span>27]<\/span><\/a><\/sup>[<\/span>28]<\/span><\/a><\/sup>[<\/span>29]<\/span><\/a><\/sup><\/p>\n

Pentobarbital can occur as a\u00a0free acid<\/a>\u00a0but is usually\u00a0formulated<\/a>\u00a0as the sodium\u00a0salt<\/a>, pentobarbital sodium. The free acid is only slightly\u00a0soluble<\/a>\u00a0in water and in\u00a0ethanol<\/a>[<\/span>30]<\/span><\/a><\/sup>[<\/span>31]<\/span><\/a><\/sup>\u00a0while the sodium salt shows better solubility.<\/p>\n

\n

Society and culture<\/h2>\n

[<\/span>edit<\/a>]<\/span><\/span><\/p>\n<\/div>\n

Pentobarbital<\/i>\u00a0is the\u00a0INN<\/a>,\u00a0AAN<\/a>,\u00a0BAN<\/a>, and\u00a0USAN<\/a>\u00a0while\u00a0pentobarbitone<\/i>\u00a0is a former AAN and BAN.<\/p>\n

One brand name for this drug is\u00a0Nembutal<\/i>, coined by John S. Lundy, who started using it in 1930, from the structural formula of the\u00a0sodium salt<\/a>\u2014Na (sodium) +\u00a0ethyl<\/a>\u00a0+\u00a0methyl<\/a>\u00a0+\u00a0butyl<\/a>\u00a0+\u00a0al<\/a>\u00a0(common\u00a0suffix<\/a>\u00a0for\u00a0barbiturates<\/a>).[<\/span>32]<\/span><\/a><\/sup>\u00a0Nembutal is trademarked and manufactured by the Danish pharmaceutical company\u00a0Lundbeck<\/a>\u00a0(now produced by Akorn Pharmaceuticals) is the only injectable form of pentobarbital approved for sale in the United States.<\/p>\n

<\/a>
Nembutal capsule<\/figcaption><\/figure>\n

Abbott<\/a>\u00a0discontinued its Nembutal brand of pentobarbital capsules in 1999, largely replaced by the benzodiazepine family of drugs. Abbott’s Nembutal, known on the streets as “yellow jackets”, was widely abused.[<\/span>33]<\/span><\/a><\/sup>[<\/span>34]<\/span><\/a><\/sup>\u00a0They were available as 30, 50, and 100 mg capsules of yellow, white-orange, and yellow colors, respectively.[<\/span>35]<\/span><\/a><\/sup><\/p>","protected":false},"excerpt":{"rendered":"CLICK TO ORDER ON WHATSAPP NOW !<\/span><\/a>\n

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<\/h3>","protected":false},"featured_media":207,"comment_status":"open","ping_status":"closed","template":"","meta":[],"product_brand":[19],"product_cat":[18],"product_tag":[43,29,33,37,28,36,30,31,32,39,38,34,35],"class_list":{"0":"post-185","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_brand-pentobarbital-sodium","7":"product_cat-nembutal","8":"product_tag-buy-nembutal-pentobarbital-sodium-online","9":"product_tag-buy-nembutal-powder-online","10":"product_tag-buy-nembutal-powder-online-usa","11":"product_tag-nembutal-powder-25g-for-sale","12":"product_tag-nembutal-powder-for-sale","13":"product_tag-nembutal-powder-near-me","14":"product_tag-nembutal-powder-online","15":"product_tag-nembutal-powder-price","16":"product_tag-nembutal-powder-shelf-life","17":"product_tag-order-nembutal-powder-25g","18":"product_tag-order-nembutal-powder-ireland","19":"product_tag-pure-nembutal-powder-online","20":"product_tag-where-to-buy-nembutal-powder","22":"first","23":"instock","24":"shipping-taxable","25":"purchasable","26":"product-type-simple"},"yoast_head":"\nNembutal Powder for Euthanasia - 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